A method for rapidly evaluating reliability and predicting remaining useful life using two-dimensional convolutional neural network with signal conversion

Journal of Mechanical Science and Technology - Real-time monitoring and rapid evaluation of bearing operating conditions, especially for the reliability evaluation and remaining useful life (RUL)...     

Research on Chromium Retrieval of Black Soil with Hyperspectral Imagery in Northeast of China#br#

According to the definition of spectral integral，a new spectral characteristic parameter，with the name Reversed Spectral Absorption Integral(RSAI)，is proposed and used to retrieve the chromium content based on the Partial Least Squares Regression(PLSR) model.The contrastive study with other traditional spectral characteristic parameters，including differential transformation，inverse transformation，absorption area，etc.indicates that(1) the first derivation of square root transformed model can predict the chromium content quantitatively in terms of spectral transformations.(2) the stability of the absorption area model is slightly poor，and the chromium content of samples can only be estimated roughly.(3) However，as to the inversed spectral absorption integral model，the adjustment determination coefficient(Ad-R²) of the modeling and verification is 0.73 and 0.77，while the Root Mean Squared Error(RMSE) is 2.63 mg/kg and 2.36 mg/kg respectively with Relative Percent Deviation(RPD) being 3.21，which shows that the RSAI model has excellent prediction ability.So，the inversed spectral absorption integral new model can improve the accuracy and stability used to retrieve the chromium content，which provides a new idea for monitoring the chromium contamination in soil.     

Automatic debugging of operator errors based on efficient mutation analysis

Multimedia Tools and Applications - It takes a lot of time and effort to manually locate and fix software bugs. This paper proposes a method for automatically debugging operator related bugs....     

Computational Fluid Dynamics Study on a Top-Blown Smelting Process with Lance Failure in an Isa Furnace

JOM - The Isa/Ausmelt smelting technology with a top submerged lance (TSL) has been extensively used in copper smelting processes. However, the TSL is extremely vulnerable to damage and failure...     

Synthesis and Preliminary Evaluation of 11C-Labeled VU0467485/AZ13713945 and Its Analogues for Imaging Muscarinic Acetylcholine Receptor Subtype 4

Muscarinic acetylcholine receptors (mAChRs) have five distinct subunits (M₁–M₅) and are involved in the action of the neurotransmitter acetylcholine in the central and peripheral nervous system. Attributed to the promising clinical efficacy of xanomeline, an M₁/M₄-preferring agonist, in patients of schizophrenia and Alzheimer's disease, M₁- or M₄-selective mAChR modulators have been developed that target the topographically distinct allosteric sites. Herein we report the synthesis and preliminary evaluation of ¹¹C-labeled positron emission tomography (PET) ligands based on a validated M₄R positive allosteric modulator VU0467485 (AZ13713945) to facilitate drug discovery. [¹¹C]VU0467485 and two other ligands were prepared in high radiochemical yields (>30 %, decay-corrected) with high radiochemical purity (>99 %) and high molar activity (>74 GBq μmol⁻¹). In vitro autoradiography studies indicated that these three ligands possess moderate-to-high in vitro specific binding to M₄R. Nevertheless, further physiochemical property optimization is necessary to overcome the challenges associated with limited brain permeability.     

Allele-Specific Inhibition of Histone Demethylases

Histone demethylases play a critical role in mammalian gene expression by removing methyl groups from lysine residues in degree- and site-specific manner. To specifically interrogate members and isoforms of this class of enzymes, we have developed demethylase variants with an expanded active site. The mutant enzymes are capable of performing lysine demethylation with wild-type proficiency, but are sensitive to inhibition by cofactor-competitive molecules embellished with a complementary steric “bump”. The selected inhibitors show more than 20-fold selectivity over the wild-type demethylase, thus overcoming issues typical to pharmacological and genetic approaches. The mutant–inhibitor pairs are shown to act on a physiologically relevant full-length substrate. By engineering a conserved amino acid to achieve member-specific perturbation, this study provides a general approach for studying histone demethylases in diverse cellular processes.     

A framework for discovering health disparities among cohorts in an influenza epidemic

World Wide Web - Infectious diseases such as Influenza and Ebola pose a serious threat to everyone but certain demographics and cohorts face a higher risk of infection than others. This research...     

热轧Φ6 ~40 mm HRB500E螺纹钢筋的生产实践

根据GB/T 1499.2-2018标准,水钢设计了Φ36～40 mm HRB500E螺纹钢筋的内控成分为（%）0.22～0.25C、0.60～0.70Si、1. 50～1.60Mn、0.11～0.13V、P≤0. 045、S≤0. 045。采用"100 t顶底复吹转炉冶炼-挡渣出钢-脱氧合金化-LF炉精炼-160方坯连铸-方坯加热-棒材轧制-空冷"的工艺流程,生产出的Φ36 mm HRB500E螺纹钢筋的屈服强度Re_L⁰ 540～580 MPa,抗拉强度R_m⁰ 705～735 MPa,断后伸长率A 15. 5%～20. 5%,最大力总延伸率A_gt 11.5%～14.0%,实测抗拉强度与实测屈服强度之比R_m⁰/R_eL⁰为1.25～1.32,实测屈服强度与GB/T 1499.2-2018标准要求的最低屈服强度之比R_eL⁰/R_eL为1.08～1.16,因此,钢筋的力学性能满足GB/T 1499.2-2018标准要求。生产出的Φ40 mm HRB500E钢筋的微观组织为铁素体+珠光体,晶粒度为9.5～10级。     

社交网络中基于网络结构支撑模型的谣言传播研究

结合结构支撑理论，探究节点网络结构支持力的一些性质，提出了社交网络结构中的全网支持力和被支持力的总量一致性，并进一步提出计算节点支持力的方法。谣言作为特殊信息，在支持力不同节点之间的传播特性有所不同，借鉴随机游走模型中的PageRank计算方法，对不同节点支持力的谣言传播以及传播后的辟谣状况进行了仿真模拟，结果表明支持力不同的节点对于谣言传播和辟谣影响明显。